In this thesis, dendritic silica mesoporous nanoparticles as new generation of mesoporous structure with some interesting features, including high specific surface area, good biocompatibility, high mechanical and thermal resistance, large pore volume which allows loading of large amounts of drug molecules, and easy surface functionalization were used for preparation of new drug delivery systems. Three projects with the main purpose of designed and synthesized of new drug delivery systems for anti-cancer drug release based on dendritic silica mesoporous were investigated. In all projects, drug delivery systems were characterized with some methods such as XRD, FT-IR, BET, DLS, Zeta-potential, FE-SEM, TGA and TEM. Drug release manner was investigated with UV-Vis and HPLC methods in solutions with the same pH of blood, tumor, and digestive system. The obtained results showed that cumulative drug release increased in the tumor pH and temperature. In all projects, the different staining methods and biological tests were used to visualize the speci?c targeting ability, cellular uptake, and the anticancer activity of synthesized compounds toward the MCF-7, A549, and Hela cancer cells in the same conditions like photothermal and sonodynamic therapy. The results proved that the combination chemo-sonodynamic and chemo-photothermal therapy are more efficient for cancer treatment compared with chemotherapy alone. In another project, the biodegradable polycaprolactone (PCL) scaffold embedded dendritic silica mesoporous loaded with Curcumine as anti-inflemtory and anti-microbial drug were designed and fabricated by electrospinning technique for bone tissue engineering application. The results reveal that some PCL properties, including nanofiber diameter, water abortion ability, contact angle, rate of degradability, and bioavailability, were improved with embedded silica mesoporous nanoparticles. The cell viability assay on MG-63 osteoblast cells confirmed that after 7 days of cell culture, cell proliferation was improved by increasing the silica mesoporous contents. Controlled and sustained release of Curcumin from fabricated scaffold reduced inflammation, swelling and also prevented infection after surgical process.
