Today, cancer is one of the most common diseases and its treatment is a priority. One of the main applications of magnetic stores is magnetic translocation for the treatment of cancerous masses, which is injected into the required area and placed in an alternating magnetic field with the help of magnetic nanoparticles, which causes heat in the range of 46-41 ° C, which causes It kills cancer cells. Intelligent drug delivery systems control the rate and type of drug release, reduce drug side effects in the body, maintain the drug concentration at a relatively constant level until it reaches the target tissue, and also increase the therapeutic effect of the drug. LDHs are a special type of layered compound whose crystal structure is made up of two-dimensional units stacked by van der Waals forces due to their high biocompatibility, high efficiency and loading density, as well as excellent protection against imported molecules. They are widely used in drug delivery to the space between their layers against unwanted degradation and decomposition. Most biomolecules are negatively charged, so they can be spaced between LDHs. LDHs have the ability to load different types of drugs for controlled release to the target tissue and significantly increase their delivery efficiency and stability. In the design of core-shell systems, the presence of a biocompatible polymer shell reduces drug side effects and more controlled and slower drug release. The aim of the present study was to fabricate and characterize core-shell nanoparticles with dual-magnetic hydroxide hybrid core and polymer shell and to investigate drug loading and release in them. Doxorubicin was selected as the study drug; Because doxorubicin is a viable option for the treatment of cancerous tumors, it is currently used in high-dose chemotherapy. For this reason, this drug has been used in the extraterrestrial method for tumor death and greater effectiveness. In this regard, in the first stage, magnetite nanoparticles and bilayer hydroxide nanosheets were fabricated by co-precipitation method and magnetite-bilayer hydroxide hybrid was synthesized. The optimal sample was selected by performing X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray emission spectrometer and Fourier transform infrared spectroscopy. Using these tests, an almost spherical morphology and average particle size for core-shell nanoparticles of 305.35 16 16.54 nm were obtained. Magnetic properties and specific loss power of nanoparticles were investigated; Magnetic properties for pure magnetite nanoparticles, dual-layer magnetite-hydroxide hybrids and core-shell nanoparticles were reported to be about 63.37 emu / g, 40.19 emu / g and 5.88 emu / g. Were measured and compared in the superheating method for the samples. Finally, doxorubicin was loaded on hybrid and core-shell nanoparticles and released in an environment with a pH of 1.5 and the first two hours at a temperature of 42 ° C and then for 48 hours at a simulated body temperature of 37 ° C were checked. key words Fe3O4, layered double hydroxide, core-shell, temperature sensitive hydrogel, PNIPAAM