laserProper mechanical properties and resistance to corrosion of zirconia is introduced as a good candidate to replace metallic endosseous dental implants especially for weight-bearing osition. But zirconia is prone to degradation proce at low temperatures and decreasing of mechanical properties,when it used in oral environment. The aim of this study was to design,fabrication and optimization of ew nanocomposite to fix the shortcomings mentioned. For this perpose zirconia stabilized with yttria(3% molar) - alumina with a volume percentage of 10,20 and 30 of alumina nano composite was prepared as a substrate and surface modification was done with hydroxiapatite-zirconia nanocomposite coate and femtosecond laser method. At first, the required samples were prepared from zirconia and zirconia stabilized with yttria(3% molar) - alumina anocomposites(90-10,80-20 and70-30). After evaluating the mechanical properties (elastic modulus, hardness, fracture toughness and biaxial strength) of studied samples: pure zirconia and nano-composites 90-10,80-20and70-30, the 80-20 nanocomposite sample was selected for modifying surface with femtosecond laser. The surface modification of zirconia stabilized with yttria (3% molar) - alumina nanocomposite (with a volume percentage of 20) was done y hydroxiapatite-zirconia nanocomposite coate , femtosecond laser and a combination of both methods. Mouse fibroblast cell culture was done o nanocomposite substrate (80-20) at three groups with different surfaces(first group: no surface modification, second group: laser surface modification, third group: combined laser surface modification and HA– Zr nanocomposite coat together). The tests of porosity measurements, densiometry, energy dispersive X-ray spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, measurement of mechanical properties (flexural strength, coefficient of elasticity, hardness and fracture toughness) was performed on nano-composite samples (90-10,80-20and70-30) and hydroxiapatite-zirconia nanocomposite coat. The evaluation of degradation at low temperature was done in an autoclave, under a temperature of 134 ° C and pressure of 2 atm on nano-composites (90-10, 80-20and70-30) samples. Also,the evaluation of morphology and microstructure of microgroove pattern and measuring the light levels of tetrazulyn turns yellow to purple formazan in living cells(MTT) was performed. The results showed that using anocomposites using zirconia - alumina nanocomposite(with a volume percentage of 20) while achieving desirable mechanical properties, low-temperature degradation process control has been achieved. In addition to more control of low temperature process is achived by uccessful appling of hydroxiapatite-zirconia nanocomposite coat. As a result, the low temperature degradation proce will be better controlled with the use of zirconia - alumina nano-composite (with 20 volume percent) and hydroxyapatite zirconia nanocomposite coating with minimal cracks. The results of studie and cell culture showed that the zirconia - alumina nanocomposite(with a volume percentage of 20) sample and using a combination of laser surface modification with hydroxyapatite-zirconia anocomposite coat was desired product while be provided the better control of the low temperature degradation process ( with hydroxiapatite-zirconia nano composite coat) also the favorable conditions would be provided to encourage and increased the osseointegration of bone tissue in contact with the modified implant surface to combined method ( laser surface modification and nanocomposite coat) .