Nowdays shipping costs are a major part of product’s expenses. Therefore, decision-makers seek to reduce shipping costs and thereby increase their profits. Routing and loading Problems are two important issues to reduce shipping costs, which in the past decade these issues had been integrated together in order to make Routing vehicles Problems Close to the ones in real-world. In practice meeting loading constraint leads to loadable goods assigned to each path. It also prevents goods damages and additional costs. In this thesis, the integrated routing problem of Pick up, delivering and backhaul with 3D loading and time window constraints is examined .the loading constraints considered are orientation, weight, stacking stability, reloading ban and LIFO constraint