: Catalytic reforming of naphtha is an important process in reforming of naphtha with low octane number to gasoline with high octane number. The rectors of catalytic reforming unit are the heart of unit. In this thesis catalytic reforming unit of Isfahan, Tabriz and Kermanshah refineries have been modeled using of four Smith, Stijpovic and et.al., Padmavathi-chaudri and so Ancheyta-Juarez kinetic types. Number of reactors in catalytic reforming unit of Kermanshah is three and in Tabriz and Isfahan is four. There is an acceptable coincidence between results of modeling and industrial data using of Stijpovic, Padmavathi and Ancheyta kinetics. Generated error of modeling use of Smith Kinetic is noticeable slightly. Results of modeling indicates that gradient rate of temperatures and concentration of matters in both Stijpovic and Padmavathi kinetic reactors is monotonic and the noted gradient rate using Smith and Ancheyta kinetics is usually fast i the initial of reactor and slow in the final of reactor. Using of Genetics Algorithm and modeling have been done on noted kinetics, the way of optimized distribution of catalyst in the reactors of catalytic reforming unit in Kermanshah refinery is 19, 29 and 52 percent respectively and in catalytic reforming unit of Isfahan and Tabriz refinery is 9, 17,27 and 47 percent respectively. By times and under various factors such as cocking, the activity of catalysts are decreased, so in order to control the drop of catalyst activity and generating gasoline with suitable octane number, entrance temperature is increased. The activity of catalysts using of processing data and presented models has been introduced in any given time and temperature by genetic algorithm. The activity has been defined in the form of a coefficient to any reactions. Finally the activity of catalysts has been specified in the form of an exponential function of time and temperature. Key words: Modeling, optimization, Genetic Algorithm, Kinetic, Deactivation of Catalyst.