Presence of pharmaceutical active compoundsin the environmentdue to the large amountsofdrugs used in medical, veterinaryandagricultural activities have been considered as an environmental problem in the developed countries in the recent decade.Earlier,the existence ofpharmaceuticals in the environment had a little importance. Although their presence was reported in sewage treatment plant effluents, it was thought thatthese compounds would be easily degraded in the environment just same as degradation inthe human body. Even thoughthesedrugsandtheirmetaboliteshave been partially eliminated intheenvironment during the adsorption, aerobic and anaerobicprocesses, they may reach the waterresources in theend.Thepharmaceuticals within thesludgecanbedegraded duringthedigestion process.However,some of thesecompoundsremained unchanged.The existence of PhACs inthe environmentand consequentlyin thewaterdue to itsadverse effectson public healthhasbeen acause ofconcern. Harmful effectsofthePhACs in environment can point to toxicityoftheaquatics, resistance development ofpathogenicbacteria, genotoxicity and endocrine disorders.Enrofloxacin is afluoroquinolone which has an antibacterial capability against many pathogenic bacteria in animals. During years of 1990-6 over 7,000 tons of antibiotics were taken in poultries of Iran. About 20% of the total taken antibiotics wasEenrofloxacin. Conventional wastewater treatment methods unable to act as a reliable process for degrade pharmaceuticals. Therefore applying advanced treatment technologies alongside the conventional methods in case of detecting these contaminants are necessary. Several methods of advanced treatment are used to achieve this goal. Chemical oxidation by chlorination and photolysis, membrane filtration such as reverse osmosis and Nano-filters and activated carbon adsorption are some of these methods. Advanced Oxidation Processes are effective in the degradation of contaminants in the water. Many drugs need to be protected against UV radiation and visible light. Drugs with low photostability would be degraded by UV Radiation. In this research all biological treatment experiments were performed in structured packing Rotating Biological Contactor.The designed bioreactorwas built of a traarent polycarbonate container. The container was composed of three distinct compartments. The media for growth of bio-film in this system was of polypropylene structured packing with the specific surface of 240 m 2 /m 3 .In the constructed system, the used packing was formed in cylinders with a diameter of 20 cm and length 30 cm.Special structure of the packing led to an appropriate mixing of liquor in the container, which reduces the possibility of formation of dead zones.The driving force for rotation of shaft and attached packing was supplied by a motor which through a gearbox. Shaft was rotated with a constant speed of 10 rpm. The spRBC was designed in for submerging of 40% of the packing in the mixed liquor.In order to create a suitable environment for the UV radiation and further oxidation of contaminants in wastewater, a setup was designed and built. The system was a triangular-shaped channel made ??by galvanized steel with length of 150 cm and 16cm for each side of triangle. A UV radiator lamp was assembled at upper section of channel. The effluent from the spRBC passes through the length of the channel. Reflection characteristic of the used galvanized sheet made the maximum usage of UV energy possible due to its reflection property. The applied UV Lamp in the system radiated wavelength between 200-280 nm and power of 13.5 Watts. After start up, the contribution rate of drug sorption by the sludge phase was high and removal efficiency of drugs was increased to 70. The maximum removal efficiency in in direct photolysis process of 98% was measured for the influent with concentration of 10 ppm in distilled water. Finally, the direct photolysis and UV/H 2 O 2 processes were .