Sulfur dioxide is one hazardous pollutants in oil and gas industries. Health, financial and environmental damages can be caused by release of this pollutant in the air. Therefore, in recent years, lots of environmental limitations have been determined by environmental communities to reduce the emission of this pollutant. Based on the above, the purpose of this study is adsorption and separation of sulfur dioxide by mixed nano CuO-Fe 2 O 3 solid sorbents based on nano TiO 2 . Sorbents were prepared by deposition/precipitation method and adsorption tests were carried out at laboratory fixed bed reactor. Selected effective parameters were chosen for sulfur dioxide adsorption, temperature, pollutant inlet concentration and sorbent type (difference in percentage of nano metal oxide loading). By using design of expert and taguchi method, experimental conditions were chosen to save time and costs. Based on isotherms that gained from adsorption performance of each adsorbent fixed bed, adsorption capacity of pollutant was calculated by integration method and was used as result to analyze with calculating software (Qualitek). Among all parameters, temperature was the most effective one. Sorbent containing 15% nano CuO- 10% nano Fe 2 O 3 and sorbents containing 17% nano CuO- 8% nano Fe 2 O 3 (in the nano CuO range of loading from 10%-22% wt. and nano Fe 2 O 3 range of loading from 15%-3% wt.), had the most adsorption capacity in the concentration range of 10,000-30,000 ppm and temperature range of 250-350 °C. Adsorption capacity of these sorbents were 63.12 mg/ (g sorbent) and 65 mg/ (g sorbent) respectively in 10,000 ppm and 350 °C. Looking to BET analysis result, specific surface area for both adsorbents are 70 and 72 m 2 /g. BJH analysis results showed maximum pore size distribution around 10 nm for adsorbent containing 17% nano CuO- 8% nano Fe 2 O 3. Considering approximately same surface area of sorbents and basing on adsorption capacities, it can be claimed that at 17% loading of n-CuO and 8% loading of n-Fe2O3 simultaneous effect of nano metal oxides were more effective.Considering to FE-SEM images, no agglomeration happened during sorbents preparation to nano metal oxide particles. Minimum size of particles for sorbent containing 15% nano CuO- 10% nano Fe 2 O 3 and sorbent containing 17% nano CuO- 8% nano Fe 2 O 3 stayed at about 23 to 50 nm and their appearance are uniform. XRD patterns showed no metal oxide spinel production due to heating operations and sorbent preparation. Moreover, same patterns yielded for both sorbents. Nano sorbents adsorption capacities were in the range of CuO/Al 2 O 3 sorbent adsorption capacity (with 250 to 300 m 2 /g specific surface area) which investigated by other researchers. Therefore, with surface reformation, granulation, sorbent strength analysis and durability analysis, it is expectable that these sorbents (as an alternative approach to amine based operations that consumed significantly amount of water and cause environmental and financial difficulties) can be used in pilot purposes. Keywords: Sulfur dioxide, Nano metal oxides, Chemisorption, Deposition/Precipitation