: The waste generated during the process of converting yellowcake into uranium hexafluoride is containing uranium compounds. The amount of uranium in these wastes is considerable because the amount of wastewater is very high and so the uranium recovery is vital and very important. The solvent extraction can be a desirable method for uranium recovery from wastes if the percentage of fluoride ions in the solution is reduced extensively. Also the storage of wastes is not economically feasible and it has many environmental problems because it has radioactive effects. The purpose of this project was to remove fluoride from uranium wastewater with silica wastes from zirconium processing company. The wastes were selected from evaporated pools having high content of sodium and fluorine ions. The mother solution was prepared based on statistical experiments design (response surface method: RSM) using the software Minitab 17. The optimum results of mother solution in the range of experiments with this method were obtained as nitric acid of 55%, temperature of 20 o c and liquid to solid mass ratio‌‌ (L/S) of 6/5, respectively. Then the silica waste was used to remove fluoride ions from wastewater. The optimal operating conditions for effective variables were obtained. The RSM analysi analysi indicated that the experimental data have a very good compatibility with second order polynomial models. R 2 and modified R 2 of the model were calculated to be 96/8% and 93/91%, respectively. The optimum conditions were predicted via RSM to be temperature of 25 o c, silica mass of 4 gr and reaction time of 70 minutes for the fluoride removal of 98/57 w/w%. The accuracy of validated with triplicate experiments giving the average extraction recovery of 98.1±1%. Keyword: Fluoride removal, Uranium, Silica, Response surface method