The increasing concerns on antibiotics in water require a prompt action to remove them in wastewater treatment processes. Efficient adsorption of amoxicillin (AMX) antibiotics from wastewater remains a serious task for public health and environmental protection. In this study, adsorptive removal of AMX antibiotic from wastewater is presented using MIL-53(Al) metal-organic framework (MOF) and montmorillonite K10 clay modified (Organoclay). These adsorbents were synthesized and characterized by N 2 adsorption-desorption isotherm (BET method), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-rey diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR), thermogravimetric (TGA), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS) and Zeta potential methods. MOF had high surface area (1288 m 2 g -1 ) and was thermally stable until temperature of 500 degrees Celsius. Organoclay was layer structure and had much interlayer space for adsorption of antibiotic. Batch adsorption experiments were carried out using MOF and organoclay. The high surface area and high porosity diameter of MOF, also the layer structure and much interlayer space of organoclay presented significant adsorption capacity with faster kinetics. About 92% of AMX was adsorbed in 10 min with both adsorbents and equilibriumed in 60 min. Kinetic data were fitted by pseudo first order model and pseudo second order model. The kinetic data were better fitted with the pseudo second order model. The isothermal data were fitted by Langmuir model and Freundlich model. The isothermal data were best fitted with the Langmuir model. The adsorption capacity of MOF at 303 K is 758.5 mg g -1 , also for organoclay at 303 K is 647.7 mg g -1 . The thermodynamic studies showed that the adsorption with both adsorbents were spontaneous and exothermic process. The high adsorption capacity of MOF is attributted to ?-? stacking, hydrogen bonding and electrostatic interactions. The high adsorption capacity of organoclay is attributted to hydrophobic interactions, hydrogen bonding and electrostatic interactions. Moreover, adsorbents showed a good reusability with the adsorption capacity decreasing about (3-5%) after reuse for four cycles.
