Continued developments in the casting techniques in the first half of the 20th, caused the invention of horizontal centrifugal casting method to produce pipes which is gradually replaced instead of sand casting method. Ductile iron pipes which were casted y same method in the De’lavuad machine, were being used as the standard pipes in modern drinking water and wastewater networks for years. The main goal of this dissertation is thermal and mechanical simulation of horizontal centrifugal casting to produce ductile iron pipe by using finite element method and finally thermal fatigue life estimation molds use in casting machines. The process is simulated in ANSYS commercial software developing related ANSYS codes (macros). In this research a numerical axisymmetric model of the pipe and mold is proposed, and history of the thermal distribution in cast and mold during solidification and thermal cycle of casting is obtained. In the simulation, initial and boundary conditions proportional to practical conditions and thermophysical properties of material which are function of temperature, are also considered. The comparison to results of the thermal simulation show good agreement with the experimental results conducted in this study and numerical results by the numerical results found in the literature. Then, the mold temperature distribution used as input data for the mechanical analysis and with regard to the mechanical properties of the mold which are function of temperature and the mechanical constraints imposed, the stress and strain generated in the cycles may be obtained. Results of the mechanical simulation show good agreement with the experimental results conducted in this study and numerical results by the numerical results found in the literature. Finally, estimated mold life with putting sustainable cycle of stress and strain values ?? ??in formulas such as Morrow or Manson – Halfrd and are compared with experimental results. The results of simulation have shown that, the maximum temperature on the mold critical point have a significant effect on the increase or decrease in the mold life. Key Words Horizontal centrifugal casting, Heat transfer, Mechanical simulation, Thermal fatigue life, FE Analysis