Nowadays, engineering structures are often subjected to repeated loading, so the evaluation of fatigue limit is definitely necessary. One of the most effective methods for fatigue life prediction is by applying the thermodynamics equations. In fatigue process, entropy is generated because of plastic deformation, heat transfer and other reversible factors. This study is intended to estimate the thermodynamic entropy of metals under cyclic loading that reaches a constant value at the point of fracture. Then by using the relation between entropy and fatigue life, we could estimate the number of cycles to fracture. Most of the energy in fatigue process is wasted in form of heat transfer. Therefore, with use of temperature evolution during fatigue process, fatigue fracture entropy of metals can be calculated. An empirical correlation of the formNf=c1*(R(teta))^c2with constants c1 and c2 is derived for tension-compression fatigue loading that relates the rate of temperature rise,R(teta) , at the beginning of the test to the number of cycles to failure,Nf . Since axial fatigue tests are expensive and time-consuming, they are replaced by a finite element analysis. In this study, Abaqus software was used for numerical simulation. Temperature evolution is obtained by subjecting an aluminum alloy 6061-T6 specimen to fully reversed tension-compression cyclic loading that is simulated by elastic-plastic finite element analysis. Since hardening parameters of Aluminum alloy 6061-T6 are not accessible, a combined hardening model of Chaboche is applied for estimating the material parameters. From stress-strain hysteresis loops results, which are obtained from experimental tension-compression fatigue tests, hardening parameters of material can be calculated. An infrared thermographic technique is used to measure the temperature increase of the specimen due to hysteresis heating during the fatigue tests and to validate of finite element results. Also, a universal curve for prediction of fatigue failure based on initial slope of temperature evolution for tension-compression fatigue loading was presented. Then, the numerical results of stress-strain hysteresis loops, temperature evaluation and entropy were in a good agreement with the experimental results. Finally, by using defined relation between entropy and temperature, the fatigue fracture entropy was achieved. Moreover, the numerical and experimental results indicated that the fatigue fracture is constant at different frequencies and stress amplitudes. Also, it was shown that the cooling operation during fatigue process, increases the fatigue life. Keywords: Fatigue life, Entropy, Tension-compression fatigue loading, Combined hardening, Numerical simulatio