In recent years, the study on porous structures has greatly boosted due to the specific behavior of these structures, including the mechanical strength properties, thermal conductivity, and the density of such structures. In addition to the intensification of the environmental pollution problem and its special attention, studies are directed toward porous biodegradable structures. Aerogels are good candidates to be mentioned among such structures. Aerogel is a structure with a porosity of more than 80%. In this dissertation, the biodegradable Aerogel was synthesized using cellulose nanofibers and its mechanical strength properties were improved using the resins synthesized before, also, mechanical properties, pressure test was performed on the synthesized Aerogels, in addition, variables of time for effect of resin, storage temperature and resin content were optimized. In order to predict the mechanical properties of Aerogels, the mechanical properties simulation was performed using CAE Abaqus finite element method to obtain a structural model of this type of Aerogel and its mechanical properties such as Elastic Modulus and Yield Stress were obtained. Keywords: Aerogel, Biodegradable, Mechanical Compressive Properties, Cellulose Nanofiber, Simulation, Finite Element, CAE Abaqus.