In this work, the dynamic deposition of particles in the lung is modeled based on the Eulerian-Eulerian approach. The whole lung is simulated and the deposition rate in each generation is derived by solving the aerosol General Dynamic Equation (GDE). All deposition mechanisms are considered and the effect of each mechanism for each particle size is studied. The one-dimensional GDE is solved by the fractional step method to obtain the size distribution of the inhaled particles in the lung. Also the alveolar region is considered to have expansion and contraction during a breathing cycle. In this article the growth and coagulation of particles are also modeled. In order to solve the GDE a computational method is implemented based on time-step splitting and subcycling approach, combined with a moving grid method for growth process. Comparison of the results with current experimental and numerical results shows a good agreement. Also it shows that larger particles deposit more on the upper region, while the smaller ones deposit more on the lower region of the lung. Including the effect of particle growth and coagulation increases the rate of deposition of smaller particles. The results show the maximum deposition occurs in right lower lobe and minimum deposition occurs in right middle lobe and that deposition fraction in Horsfield’s model is lower than Weibel’s model