Drop impact on solid surface has many industrial applications such as surface coating, steam turbines, spray cooling, erosion of soils, fuel injection in engines, forensic medicine,ink-jet printing and many other applications in chemical processes. Limitations in experimental and analytical methods for exploiting behavior of mesoscale drops during the impact to the rigid surfaces, conduct us to use numerical simulation for this study. Methods like Monte carlo and molecular dynamics have been used to analyze the statics and dynamics of drop on solid surface but these methods are limited to small time and length scales. To solve these problems, a three dimensional particle-based method called Many-body Dissipative Particle Dynamics (MDPD) which can be used at meso-level simulations is selected and used in this project.In MDPD, soft-core potential is used and dissipative, random and conservative forces are the three forces that act on any particle according to Newton’s second and third laws.Like standard DPD method, dissipative and random forces are used to produce viscous effects and account for the lost degrees of freedom because of coarse-graining, respectively. MDPD differs from its predecessor, DPD method in the definition of conservative forces acting between particles. In DPD, conservative force is added to account for non-ideality of the system and only contains a repulsive term. In MDPD, rather than assuming the dependence of the force on the interparticle separation, repulsive term is made additionally dependent on the instantaneous local particle density and an attractive term is added to the conservative force that acts on a longer range than repulsive term for each particle. Solid surface contains freezing particles which don’t move but interact with liquid particles. Hydrophobic and hydrophilic surfaces can be modeled by changing the liquid-solid conservative force amplitude and color function is used for measuring the drop static contact angle on the solid surface. In this project the influence of patterned substrates on the static contact angle is also exploited by simulating surfaces in various surface fractions and their results are compared with Cassie-Baxter's law. Dynamic wetting is studied by simulating the drop impact on horizontal and homogeneous surface in this work. In this work dimensionless drop diameter change and dimensionless drop height change versus dimensionless time are compared with experimental results at three static contact angles. For searching the influence of surface energy on drop spreading process, drop impact in various We numbers are simulated and their dimensionless drop height change and dimensionless drop diameter change diagrams are compared. Key words : Many-body Dissipative Particle Dynamics, Nanodrop, Hydrophobic surface, Hydrophilic surface, Wettability, Drop impact, Drop spread