In recent years, many efforts have been devoted to analysis of reological and thermal behaviors of nanofluids. The present research is a numerical study of heat transfer and pressure drop of two nanofluids including water and ethylene glycol-water as base fluid with and nano particles through a axisymmetric sinusoidal walled tube. In this research, numerical investigation has been done for various combinations of base fluid, nanoparticle size and concentration through straight and sinusoidal tube. Simulation has been done using Ansys CFX software in laminar flow. Besides, the thermal boundary condition of constant uniform heat flux on the tube wall was applied. The results show that the increase of Reynolds number and nano particle volume concentration have considerable effects on the heat transfer coefficient enhancement. With similar Reynolds number and volume concentration, the nanofluid with has higher heat transfer coefficient than that of especially at higher nano particle concentrations. Furthermore, the amount of heat transfer enhancement with volume concentration increment in ethylene glycol-water base fluid is more considerable than that of water for two nano particle types especially for .For two types of nano particles, the heat transfer coefficient is decreased with nano particle diameter increase. At constant Reynolds numbers and volume concentrations, the longer wave amplitude can increase heat transfer coefficient, thus the sinusoidal tube can improve the thermal performance of nanofluids. Two passive methods which used in this study lead to higher pressure drops. For all the fluids under consideration in this study, pressure drop escalates with Reynolds number. Addition of nanoparticle to base fluid leads to rise in pressure drop and this effect is more vigorous for higher concentration. Regardless to the nano particle type and its volume concentration, the skin friction coefficient decreases with Reynolds number increase. But at constant Reynolds number, longer wave amplitude results in higher friction coefficient. Both effects of pressure drop and heat transfer of fluid flow have been investigated simultaneously by using performance evaluation criteria.Similar to base fluid, the performance evaluation criteria is reduced with Reynolds number increase. Moreover, at constant Reynolds numbers, the performance evaluation criteria decreases with volume concentration increase. The results show that in high wave amplitude sinusoidal tubes, performance evaluation criteria deteriorate; but, in low amplitudes, sinusoidal tubes have better performances than straight ones. Keywords: Heat transfer, Nanofluid, Sinusoidal tube, Pressure drop, Performance evaluation criteria, Constant heat fluxt