Coronary artery disease is one of the most common diseases in human societies. Clogged arteries are caused by the formation of arterial plaques due to the growth of smooth muscle cells and the formation of a lipid nucleus in the walls of the arteries. One way to treat clogged arteries is to use stents. However, in this method, after a while, you can see the proliferation of smooth muscle cells and as a result, re-stenosis in the stenting area. Drug eluting stents are used to prevent this lesion. In the present study, the fast release drug eluting stent with 10 struts was simulated symmetrically and the equations of blood flow and blood plasma in the multilayered and porous wall along with the equations of drug transfer and reversible chemical reaction of drug particles with smooth muscle cells were solved by finite element method. In this study, the effect of plasma flow in the vessel wall and the effect of non-Newtonian blood and plasma behavior on drug distribution were investigated and the non-dimentional quantities that affected the release and transfer of two widely used drugs, sirolimus and Paclitaxel, were studied. Then, the effect of embedment of stent struts in the wall, blood pressure and Reynolds number and finally the effect of degradability of stent coating on drug distribution have been studied. results showed that the presence of plasma flow in the vessel wall accelerates the drug transfer in the vessel wall. Consideration of non-Newtonian blood behavior also showed that the flow recirculation zones around the small stent struts became smaller, resulting in higher concentrations on the surface between the stent and artery wall, which is important in predicting late thrombosis. The results also showed that the non-Newtonian behavior of Plasma can affect the amount of drug concentration in the vessel wall at the first phase of its release and increase its concentration in the artery wall as well as the time to reach maximum concentrations. Finally, the degradability results of the polymer coating showed that the bare metal stent reaches the maximum concentration in the wall sooner and the concentration amount gradually decreases, while in the biodegradable stent it reaches the maximum concentration amount a few minutes later. Keywords: Drug eluting stents, Drug transfer, non-Newtonian plasma, Multi-Layer Wall
