Nowadays, due to the limitations in the number of donors, researchers have gone towards tissue engineering and especially the fabrication of bone scaffolds. Bone tissue engineering as a multidisciplinary field containing engineering, medicine, and material science has a vast development with the assistance of additive manufacturing technology. Natural bone structure include micro/nano organic-inorganic composite, where apatite nanocrystals are precipitated on collagen fibers. Hence, for obtaining scaffolds with similar mechanical and biological properties with the real bone various techniques are combined. The aim of this research is the fabrication of hybrid bone scaffolds including micro struts of poly lactic acid (PLA) and micro/nano composite fibers of forsterite/gelatin. For this purpose, fused deposition modeling (FDM) system and electrospinning method were combined. PLA is a biocompatible and biodegradable polymer that with the aid of nano-particles of bioceramic forsterite could enhance its mechanical and biological properties so that it could be used in tissue engineering. In addition, utilizing gelatin as a natural polymer could improve the probability of initial cell attachment. Evaluating the fabricated hybrid scaffolds was done by performing mechanical experiments and biological in-vitro and in-vivo tests. Moreover, a finite element model was developed in order to anticipate the mechanical behavior of the fabricated scaffolds. Performed compression tests were showed that hybrid scaffolds had higher elastic modulus rather than pure scaffolds due to the addition of the ceramic nano-particles. Fabricated scaffolds were evaluated via simulated body fluid. The obtained results confirmed the bioactivity of the hybrid scaffolds. Furthermore, according to the performed animal study and its initial results, it was concluded that the prepared hybrid scaffold could satisfy both biological and mechanical requirements recommended by bone tissue engineering. Finally, customized bone scaffolds were designed and fabricated. Such custom-made bone scaffolds could be used as implants which lead to a considerable decrease in the time required for a surgery. Keywords: Additive manufacturing, Fused deposition modeling, Electrospinning, Forsterite, Gelatin, Hybrid scaffolds, Customized scaffolds