Pre-constructed concrete systems can greatly lead to a practical-economic solution to construct various buildings. Within the recent years, lots of research studies have been implemented to investigate the connection in pre-constructed concrete elements. Certain benefits of hybrid connections as a promising finding through wide research studies recently conducted into characterization of connections between pre-constructed concrete elements, allow designers to safely utilize pre-constructed concrete elements in the seismic regions. In such a connection, utilizing the simultaneous use of post-tensioning tendons (or cables) along with ductile steel bars shear force and bending moment are transferred. The compressive force developed at the location of beam-column connection resulting from the cable post-tensioning force, leads the shear force to be transferred because of the friction generated between beam and column. The yield of flexural steel bars located at either top or bottom of the connection section in tensile or compressive loading, are considered as the major reason for the system energy dissipation. Nowadays, the equivalent static method is presented as a structure seismic design method by most of the provisions. In this method, structure reduction factor is the most important parameter representing structure reduction along non-elastic zone. In these provisions, reduction factor is presented as constant coefficients only for some common structural systems. However, structure reduction factor depends on various parameters including structure vibration time period, ductility and site soil type where the structure is built. Since parameters such as ductility and structure vibration time period are different from each other in pre-constructed and in-place concrete elements, consequently, the respective structure reduction factors according to these systems are different as well. Hence, it is necessary to introduce an approach to determine the reduction factor in pre-constructed elements. In the current study, the reduction factor for pre-constructed concrete structures having hybrid connections is investigated using Perform 3D software. Frames in this study include the moment frames with hybrid connections and dual systems with post-tensioning shear walls. The frames may be 4, 8 or 12-story and may be 1, 3 or 5-span type. Post-tensioning percentage of hybrid connections, number of stories, number of spans and lateral load pattern are among the factors investigated in this study. In addition, accurate comparisons will be made between results obtained from analysis of pre-constructed and in-place frames. The mean reduction factors determined for in-place moment and dual frames were respectively 5.28 and 6.75 which are a little bit higher than those estimated by provision models. Moreover, the average reduction factors obtained respectively for pre-constructed moment and dual frames were 4.57 and 5.50, which are of lower values compared to those obtained for in-place frames.