In recent decades, the problem of water pollution has become more serioues. MTBE is one of the most commonly used hydrocarbon compounds of crude oil, leaking from reservoirs to groundwater. The use of MTBE in gasoline compounds has been significantly enhanced, causing high contamination of groundwater. In this study, reactive permeable walls technology is used to remove MTBE from water. This research was carried out in four phases, in which four adsorbents investigated the removal of MTBE. After much research on the removal of MTBE from groundwater, it can be said that it’s the first time these four adsorbents are investigated in the removal of MTBE from water. Control experiments were carried out in both columns and batch mode. Each phase consists of batch and columns tests to evaluate the removal of MTBE from water. The main objective of the batch experiments in this study was to assess the possibility of removing MTBE by four aerogel, mineral silicate-kyanite, andalusite, and tourmaline absorbent, and generally evaluate the proper design of suitable absorbent for application in the laboratory-simulated PRB substrate. The capacity of these four adsorbents in the batch experiments was 6.25 mgMTBE / gAerogel, 5.8 mgMTBE / gSillimanite, 4.9 mgMTBE / gAndalusite, 5.1 mg MTBE / gTourmaline. Also, the equilibrium time determined in the batch experiments for four aerogel, sillimanite-kyanite, andalusite, and tourmaline absorbents, wa 60, 240, 240, and 240 minutes, respectively. This time was equal for the three minerals of sillimanite-kyanite, andalusite and tourmaline. Then, the effect of pH on the removal efficiency of MTBE by adsorbents was investigated, which did not show any significant change with pH changes. Also, the process of MTBE removal was studied by continuous experiments. Four adsorbents, as mentioned above, were used in the simulated PRB column bed. In each absorption capacity experiment, absorption capacity was calculated for these adsorbents, 13.4 mgMTBE / g Aerogel, 4.2 mgMTBE / gSillimanite, 2.24 mg MTBE / gAndalusite and 3.72 mg MTBE / g Tourmaline. Also, the method of calculating bed life and its results were examined. According to the obtained results, the bed life for aerogel, sillimanite-kyanite, andalusite, and tourmaline adsorbents used in PRB bed was calculated 160, 290, 107, 224 minute, respectively. At last, the columns were modeled by the neural network. Key Words Aerogel, Sillimanite-Kyanite, tourmaline, PRB, Regression