Due to the spread of different diseases, physicians use various medical imaging strategies to diagnose the disease. In most cases, early diagnosis of a variety of diseases can help treat them on time. The biopsy tissue is one of the ways to diagnose the disease. Microscopic examination of sampled tissue, known as histopathology, is widely used to diagnose and In terms of Keywords: Biopsy tissue, Histopathology Images, Medical Image Processing, Segmentation,