Recently, experimental evidences have strengthened the hypothesis that biological systems may use quantum effects for their efficient functions. Here, we investigate ion channels in general and then focus on the small nanoscale part of ion channels in the excitable cells which is called "selectivity filter". First, we discuss about the possibility of quantum effects in the selectivity filter in ion channels that may have important role(s)to explain different aspects of spike generation in excitable cells by using Hodgkin-Huxley model with considering real structure of ion channels . Here, we examine parameters in a generalized model of HH to see that whether any parameter affects the spike generation and then investigate different decoherence mechanisms regarding the quantum dynamics and energy transfer in these structures. We will show that brain processes may be derived from quantum effects in nanostructures in neurons because of large decoherence time.