In this research, nanoparticles of cobalt ferrite spinel were prepared by a modified sol-gel method using Fe(NO 3 ) 3 .9 H 2 O and Co(NO 3 ) 2 .6H 2 O as the sources of Fe 3+ and Co 2+ and different volumes of herb extract and sucrose as gel agent, chelating agent and including nonmagnetic elements such as calcium and magnesium. The nanoparticles were characterization by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy(FE-SEM), elemental analysis (EDS, MAPP) and vibrating sample magnetometer (VSM). The x-ray diffraction results confirmed the formation of single-phase cobalt ferritespinel nanoparticles with a cubic crystal structure at 750°C. The average crystallite’s size was calculated about 33 nm using the Debye –Scherrer equation. Scanning electron microscopywas also showed that the prepared nanoparticles havea cubic morphology. The magnetic properties of the synthesized nanoparticles were also determined using a vibrating sample magnetometer, which revealed a saturated magnetization of 64 emu.g -1 for sample S3. The nanoparticles were then coated by chitosan as a bio-degradable and biocompatible polymer to use as a carrier for drug delivery. The antioxidant Doxorrubicin drug was then coated on the surface of the nanoparticles, and its drug release from the substrate of coated nanoparticles containing doxorubicin was elaluated at different pH levels.