In this study different series of novel poly(imide-urethane)s (PIUs) were prepared by the reaction of chiral diols with various aromatic and aliphatic diisocyanates in common solvent and the presence of DBTDL as catalyst. First chiral diols ( N,N?-(pyromellitoyl)-bis-(L-phenylalanine)diol (p2), N,N?-(4,4-'carbonyl-diphthaloyl)-bis-(L-phenylalanine)diol (p4) and N,N?-(naphtalen-diimidyl)-bis-( L-phenylalanine)diol (p6) ) were prepared by reaction of L-phenylalaninol and dianhydrides. Diols were obtained in high yield and characterized with FT-IR, 1 H NMR and 13 CNMR . The specific rotation data confirmed the optical activity induction due to successfully insertion of L-phenylalaninol in structure of diols. These novel chiral diols have been used in the synthesis of chiral polymers and also due to the presence of imide group in their structures, they can be used for the synthesis of thermal stable polymers. Condensation Polymerization of diols with diisocyanates for synthesis of poly(imide-urthane)s (PIU)s performed i common solvents under refluxing conditions or graduation heating. The resulting new polymers were obtained in good yields and their inherent viscosities were ranging between 0.18 and 0.38 dLg -1 . The polymers were characterized with FT-IR, 1 H NMR and thermo gravimetric analysis techniques (DSC and TGA). The specific rotation data confirmed their optical activity induction in their structure.