We report here, a green approach toward the synthesis of novel optically active poly(amide-imide)s bearing thiazole moietywhich condensed from the reaction of 3,5-diamino- N -(thiazol-2-yl)benzamide and diacids containing various amino acids in molten tetrabutylammonium bromide. A novel diamine monomer was synthesized via reduction of 3,5-dinitro- N -(thiazol-2-yl)benzamide by iron oxide hydroxide catalyst in methanol. This catalyst can be reducing the sulphur and azo-containing aromatic nitro compounds rapidly to the corresponding amines in high yield by employing hydrazine hydrate as a hydrogen donor and we report novel optically active poly(amide-imide)/ZnObionanocomposites(PAI/ZnO BNCs) containing L-valine moiety in the main chain were prepared via a simple and inexpensive ultrasonic irradiation process.PAI/ZnO BNCs containing 4, 8, and 12% of nanoparticles were successfully fabricated through ultrasonic irradiation technique. The obtained BNCs were characterized by Fourier transform-infrared (FT-IR) spectroscopy, thermogravimetry analysis, X-ray powder diffraction, UV–Vis spectroscopy, field emission-scanning electron microscopy (FE-SEM), and transmission electron microscopy (TEM).Thermogravimetric analysis data indicated an increase thermal stability of the BNC polymersin compared to the pure polymer. From TEM image of PAI/ZnO BNCsit can be found that the surface modified ZnO nanoparticles with less than 35 nm diametric size, uniformly dispersed in the obtained PAI matrix.