In this study, chiral and biodegradable polymer nanocomposites (NC)s based on amino acid were synthesized. For this purpose, at first, various kinds of bioactive dicarboxylic acids containing different amino acids have been used as modifiers (coupling agent) for the surface modification of nanozirconia. Trimellitic anhydride and L-amino acids (L-alanine, L-leucine, L-methionine, L-phenylalanine and L-valine) have been used for the preparation of optically active diacids. Ultrasonic method is used as a technique for the modification. Different interactions between modifiers and hydroxyl groups on the surface of nanoparticles (NP)s, make them to be changed from hydrophilic nature to hydrophobic character. As a result of repulsive forces between modified , they can better disperse. FT-IR, XDR, TGA, FE-SEM and TEM were performed on prepared samples to show successfully modification of nano ZrO 2 . Then, the modified ZrO 2 with N -trimellitylimido-L-leucine was selected for incorporation in polymer matrix. In order to achieve a better dispersion of into the polymer matrix, the same diacid was used in the structure of polymer. So, a high-performance poly(amide-imide) (PAI) from the polycondensation reaction between 4,4?-diaminediphenylsulphone and bioactive dicarboxylic acid N -trimellitylimido-L-leucine through a green media was synthesized. In this reaction triphenyl phosphite and tetra-n-butylammonium bromide are used as condensing agent and suitable media without using any organic solvent and catalyst. Incorporation of different weight percent of modified ZrO 2 into this polymeric matrix, produced nanocomposites (NC)s with improved properties. Ultrasonic technique was used for homogeneous dispersion of in the PAI matrix. Finally, resultants NCs were characterized by FT-IR, XDR, TGA, FE-SEM and TEM.
