Nanomaterial-based drug carriers have become a hot spot of research at the interface of nanotechnology and biomedicine because they allow efficient loading, targeted delivery, and controlled release of drugs, and therefore are promising for biomedical applications. In this work, a series of nanohybrid composites of doxorubicin (DOX), as an anticancer drug, graphene oxide (GO), Fe 3 O 4 coated with TiO 2 , GO-Fe 3 O 4 /DOX@TiO 2 , were synthesized and the drug release of the composites was investigated by using UV-Vis spectroscopy. Different composites of GO-Fe 3 O 4 /DOX (10-40 wt%) were prepared by dispersing GO-Fe 3 O 4 in water containing a specific concentration of DOX. The nanohybrid composites of GO-Fe 3 O 4 were coated with different amounts of TiO 2 (30-60 wt%). The nanohybrid composites of GO-Fe 3 O 4 /DOX@TiO 2 were characterized by FT-IR, FE-SEM, TGA, DSC, DLS, and BET analysis. The mesoporous coating of TiO 2 could enhance entrapment of doxorubicin considerably, and reduce the drug release.
