In this project, destructive drug delivery of zinc(II) ion with essential oil medicines such as Fennel was done through two methods. Loading the essence with organic solution in foamed composite and loading with supercritical carbon dioxide were carried out and compared together. In order to design the test, related to essence loading with supercritical carbon dioxide, Minitab 16 software and Central Cubic Design response surface method (CCD) was used by considering two factors of pressure and saturation time. Models of loaded essence yield were obtained in the form of second order formulation with two factors. Experiments designed (DOE) was carried out by considering 5 surfaces for each factor and in the operating conditions including the pressure of 80-200 bar and saturation time of 8-24 h. The optimized operating conditions for achieving the maximum amount of essence loading percentage with supercritical carbon dioxide were obtained as the pressure of 80 bar and saturation time of 24 h, pressure decrease time of 30 min, and temperature of 40?C. What is more, at 41?C, pressure of 160 bar, saturation time of 16 h and foaming time of 15 S included the proper operating condition for foaming poly ethylene glycol. The obtained foam was investigated by scanning electron microscopy. The results of comparing the two above mentioned methods show that more loading occurs with organic solvent. In order to determine the concentration of released zinc (II) ion in this conditions, atomic absorption instrument was used zinc(II) and essence release diagram in blood plasma was drawn using the results of Uv-vis spectrophotometer.