In the first section of this thesis,di-nuclear cyclopalladated chloro-bridge complexes derived from primary ,secondry and tertiary benzylamines were prepared.monodentate and bidentate ligands can split the chloro-bridges to give monomeric and dimeric complexes.reaction between chloro-bridge dimers with dithizone in the 1:1 molar ratio resulted in the Mononuclear Pd(II) complexes and reaction between chloro-bridge dimers with 3,5-Dimethylpyrazole in the 1:1 molar ratio resulted in the pyrazole-bridged Pd(II) complexes.also In second section, the phosphorus ylides R 3 PdCHC(O)PhR (R= OMe and Ph) react with the 1,5-cyclooctadiene complex [PdCl 2 (COD)]; COD =C 8 H 12 =1,5-cyclooctadiene) to give the monomeric cyclooctenyl complexes [PdCl 2 {C 8 H 12 {CH(PPh 3 )C-(O)PhR}}] (R = OMe , Ph ) which synthesized and fully characterized by elemental analysis and spectroscopic studies (IR and multi nuclear NMR). In the second part of the project, biological activity of the [Pd 2 {(C,N)-C 6 H 4 CH(CH 3 )NH 2 } 2 (µ- dmPz)] 2 ] , [PdCl 2 {C 8 H 12 {CH(PPh 3 )COC 6 H 4 -Ph-4}], [PdCl 2 {C 8 H 12 {CH(PPh 3 )COC 6 H 4 -4-OMe}] complexes was evaluated by examining their ability to bind to DNA(CT-DNA) using uv-visible and thermal denaturation. Competitive studies of sitemarkers of ibuprofen and warfarine and digoxin were also performed to identify the binding site of the complex to BSA, and as a result of the experiments, complex (3b) have been placed in binding site II, and complexe (2d) and (2f) have been placed in binding site III .