Controlling the moisture around wound, removing exudates during the treatment and elimination of harmful bacteria are some of the important factors in wound healing. With arrival of hydrogels in modern technology of bandage production, the wound moisture dramatically becomes controllable. Hydrogels are able to absorb large amount of water. In addition, depending on the structure of the molecular chains of hydrogel component, drug loading such as some of antibacterial agent is possible. Therefore, using hydrogels in wound dressing systems not only enhance the absorption of wound exudate and controls humidity but also support drugs loading in dressing. In this study, already synthesized acrylates hydrogels were incorporated into cotton fabric as substrate for wound dressin. Various coating techniques and materials including application of synthetic and natural plasticizers and binder were experienced. However, efficient coating due to high inflation and network properties of hydrogels was not possible. In addition, moisture uptake and adhesion fastness of hydrogel on dressing decreased sharply. In the next step, polyvinyl alcohol/honey hydrogel was synthesized using different acids as crosslinking agent. FTIR spectroscopy and scanning electron microscopy were used to study hydrogel structural properties. Degradation in boiling water and swelling of the hydrogel survey showed that crosslinking of the polymer is created and stable hydrogel with up to 1045 percent inflation has been prepared. propolis as an anti-bacterial and healing contributory factors was incorporated into the polyvinyl alcohol/honey hydrogel and different form of films, coatings and nano-fiber dressing were prepared. Produced hydrogel showed excellent antibacterial properties against gram-positive bacteria Staphylococcus aureus with 24 mm inhibition zone. SEM images showed porosity in the hydrogel films and bead formation containing honey on the nano web with fiber’s diameter of about 400 nm. Keywords: Hydrogel, Polyvinyl alcohol, Honey, Propolis, Wound dressing
