In recent years, medical textiles and wound dressing have been developed. The most popular wound dressings that nowadays are used include hydrogels, hydrocolloids, alginates, foams and films. Each of them have different application depending on their properties and the type of wound. Recently hydrogels have been considered in the medical field because of their properties specially high water absorption enable them to absorb wound exudates. Also this materials can be loaded with various pharmacological agents such as antibacterials, growth factors and etc for controlled release on the wound surface. In this study, soy isolated protein (SPI) hydrogel was prepared by thermal method and its water uptake capacity was evaluated using swelling test. Then the prepared hydrogel was loaded with Gabapentin as a known atractic drug and its release from the hydrogel matrix was measured by spectrophotometer. Due to poor mechanical properties of hydrogels, usually a secondary dressing should be applied to hold them on wound. Polyester fabric was used as a substrate to support SPI hydrogel . Due to hydrophobic nature of PET fabric and lack of functional groups on the surface, the surface of PET fabric was modified using two different methods: acrylic acid graft polymerization and alkaline hydrolysis of PET fabricand then soy hydrogel grafted to the surface of PET fabric modified with two aformentioned methods. ATR-FTIR technique was used to investigate the grafting of soy hydrogel on the surface of PET fabric. The results showed that SPI hydrogel can graft on the surface of PET fabric modified by acrylic acid graft polymerization. the results of drug release showed that the speed of Gabapentin delivery from the SPI hydrogel matrix is very fast and whole of the drug release in less than 24 hours. our overall results showed that PET fabric coated with SPI hydrogel containning Gabapentin can be used as an appropriate substrate for wound dressing application. Key words :Wound dressing, Hydrogel, Soy isolated protein, Polyester, Surface modification
