With the advent of science and the spread of technology, the use of nanotechnology in the medical field is the latest in the world. Nanotechnology-based drug delivery systems can be considered as a good alternative to conventional chemotherapy for treating a variety of cancerous diseases. Controlled release systems based nanofibers are one of the newest methods for delivering medication purposefully. With the help of nanofiber systems, it is possible to control the amount, timing and extent of drug release with minimal damage to healthy tissues of the body. 5-fluorouracil is one of the common drug used to treat breast, neck and intestinal cancer. This drug is very hydrophilic and can be stored for a short period of time within plain and simple fiber systems. In this study, with the help of a multi-component system, which includes nanofibrous core shell, which is the core of polyvinylpyrrolidone,shell is a combination of polymers of polyvinylpyrrolidone and poly-caprolactone and carbon nanotubes. The core-shell nanofibers were coated with an intrinsically conductive polypyrrole polymer. 5-fluorouracil-mediated drug in the core is due to the rapid degradation of the polymer of polyvinylpyrrolidone and the relatively long-term degradation of the poly-caprolactone polymer in the biological environment of the body, as well as the contraction of the structure through the flow of electricity as an external stimulus from the inside The system is controlled in a controlled manner. The reason for the electrical stimulus is superior to other stimulants in the absence of the need for large and advanced equipment, as well as the ease of production and control of electrical signals, which can be used in sensitive areas of the body where there is no possibility of using other vehicles to control the release of the drug. In the present study, 9 samples of core-shell nanofibers consisting of poly-caprolactone and olyvinylpyrrolidone polymers were considered to be identical in terms of core mass (polyvinylprolidone) and crust (poly-caprolactone: polyvinylpyrrolidone with a composition of 100: 0, 75:25 and 50:50) In such a shell section, the 0, 0.3 and 0.6% carbon nanotubes were also added to each compound. The concentration of polymeric solution was 12% polycaprolactone and polyvinylpyrrolidone 7% w / w. Electrospinning were carried out under conditions of temperature and humidity of the medium at a voltage of 15 KV and a working distance of 15 cm. The core flow rate was 0.4 and the feed rate of the shell was 0.08 ml / h. In drug loaded samples, the drug was loaded at 5,7and 10% relative to the core polymer mass in the core, according to the experimental design. In the first stage, the viscosity of the solutions, morphology and mechanical properties and the percentage of weight loss of non-drug loaded samples were examined. The results showed that with increasing polyvinyl pyrrolidone, viscosity increased significantly, and the diameter increased and tensile strength decreased statistically and led to an increase in weight loss of the solution of phosphate buffer saline. Infrared spectroscopy was performed with Fourier transform to investigate possible interactions between polymers, drugs and carbon nanotubes, which did not show any destructive interactions. Using a transmition electron microscope, the core-shell structure of the fiber was characterized by the appropriate distribution of the crust around the core. According to the experimental design, the drug was considered to be 7.5 and 10% relative to brain weight and loaded into the brain. The release of the drug was studied with spectra obtained from the spectrophotometer. The samples were all analyzed in two stages, and the Atneshar index and the kinetic model of the drug were analyzed using the Pepsa, zero order, first order and Higuchi equations, the samples being subjected to a mechanism Fiki and the Higuchi model. The optimal release sample was determined and then polypyrrol synthesis was performed on a vapour phase method, which was not evaluated desirable. Synthesis was carried out in situ, which was desirable, and the release of conventional, uncontrolled and field-tested samples was investigated. The results showed that the electrical stimulus could be considered as a control agent for release.