Heavy metal toxicity is one of the major current environmental health problems and it is potentially for human consumption dangerous due to bioaccumulation through the food chain and in plant products. A growing demand for irrigation water has produced a marked increase in the reuse of treated and/or untreated industrial and municipal wastewater, worldwide. Heavy metals in wastewater come from industries and municipal sewage, and they are one of the main causes of water and soil pollution. Among heavy metals cadmium accumulates more in plants and by increasing the cadmium level in soil its concentration in plants increases significantly. The availability of metal in contaminated soil can be reduced by the addition of soil amendments. The objectives of this study were to evaluate the application effects of pumice and zeolite as soil amendments on soil DTPA extractable and the uptake of Cd by spinach ( Spinacia Oleares L.) grown in three different conditions: (1) irrigation with wastewater (containing 10 ppm Cd), (2) a Cd-contaminated soil (25 mg/kg soil) and (3) irrigation with wastewater (containing 10 ppm Cd) in Cd-contaminated soil (25 mg/kg soil). In each of conditions, the experiment was conducted as a completely randomized design in a green house with 3 replications. Different levels of pumice (0, 4 and 8 g/100 g soil) and zeoilte (0, 1 and 5 g/100 g soil) were added to soil. The results indicated that, the addition of pumice (4 and 8 g/100 g soil) and zeolite (just 1 g/100 g soil) in soil treated with wastewater reduced cadmium concentration in root of spinach. But this effect on concentration of shoot Cd was not significant (P 0.05). The percentage of DTPA extractable Cd in soils amended with pumice (8%) and zeolite (1%) was decreased significantly, and this resulted in lower Cd accumulation in plant. Application of zeolite at 5% level, had no significant effect on cadmium concentration in plant, but this treatment increased the percentage of soil DTPA extractable Cd and also increased soil salinity. Spinach biomass and yield did not differ significantly among the treatments under irrigation by wastewater. But irrigation with wastewater containing Cd caused a decrease in biomass and yield comparison with water. Also soil salinity increased after irrigation with wastewater. Concentration of Cd was higher in shoots than in roots. Cadmium transfer factor from soil to plant was found significantly higher in 5% zeolite application and control than other treatments. Moreover zeolite (5%) increased Cd content in shoot, significantly (P 0.05). In Cd-contaminated soil (25 mg/kg soil) irrigated with water and wastewater, zeolite (5%) showed maximum concentration of cadmium in plant, and the maximum percentage of soil DTPA extractable Cd, that was significantly higher than other treatments. Other treatments except zeolite (1%), increased cadmium concentration in plant which did not show significant different with control. Zeoilte (5%) and pumice (8%) had the highest cadmium transfer factor from soil to plant. The concentration of Cd was higher in roots than in shoots. Zeolite and pumice hadn’t significant effect on biomass. But presence of cadmium was found to reduce it. In each of three conditions of this study, Cd concentration in plant was positively correlated with the percentage of soil DTPA extractable Cd. Also addition of zeoilite at 1% level was effective in reducing the adsorption of cadmium in plant. Keywords : Cadmium, Heavy metal, Pumice, Spinach, Wastewater, Zeolite.