In recent years, using of drip-tape irrigation systems has been developed for row crops. Investigation of irrigation management and drip-tape spacing for crops such as wheat, which one drip line irrigates several rows of wheat, is necessary. The purpose of this study were to compare yield and water use efficiency of wheat under two irrigation systems and calibrate and evaluate of the CERES-Wheat model for east of Isfahan province. The experimental treatments consist of two irrigation system (drip-tape and surface irrigation) and three different irrigation levels (a full irrigation level (W1), two deficit irrigation levels, applied half of irrigation depth of W1 level (W2), the irrigation interval twice of W1 level (W3). In both irrigation systems, the highest yield was observed for full irrigation level. In drip irrigation system the highest water use efficiency was in irrigation management with short irrigation interval (W2) of 1.44 kg/m3. In the surface irrigation system, the highest water use efficiency observed in irrigation management with high irrigation interval (W3) is 1.46 kg /m3. Using the field data and using the trial and error method in the CERES-Wheat model, the genetic coefficient of the Pishtaz cultivar were P1V = 3.43, P1D = 42.2, P5 = 338.6, G1 = 14, G2 = 51, G3 = 1.5 and PHINT = 63. The statistical indices were used to check the accuracy of the model in simulation. The value of RMSE index for harvest indexes including final yield, harvest index, leaf area index, total biomass and grain weight were 146 kg / ha, 0.012, 0.071, 453 kg / ha and 2 mg, respectively. For all of the crop indices the normalized root mean square error (NRMSE) values was ??less than 20% which indicates the accuracy of the model. Key words : drip-tape irrigation, CERES-Wheat, DSSAT, Water use efficiency, wheat