About one-third of world lands have rainfall deficit and Iran with approximately 250 mm rainfall in a year is ismutase in two treatments of 50 and 75% field capacity.Results of field cultivation showed that there is significant difference between %100-%75 field capacity with %50 field capacity and natural situation treatment in plant crown cover area. Drought stress had significantly affected height of plants.The diagnol of flowering stem had not affected by drought stress but the numbers of them changed significantly.Drought stress had affected number and diagnol of flowers such that there was a difference between %100-%75field capacity with %50 field capacity and natural situation treatments.Drought stress doesn’t affected the time of formation of flowering stem, time of starting flowering, flowering diuration and time of establishment of fruiting.Proline and soulable carbohydrate increased significantly. As a result this plant has optimum growth in %100 and %75 field capacity.Although its growth limited in %50 field capacity and natural situation but it doesn’t disappread. Key words: Isatis cappadocica , drought stress, proline, antioxidant enzymes, soulable carbohydrate.