Hydroponic growing systems have been developed to improve the yield and quality of crops, to preserve water and land, to decrease the labor cost and to protect the environment. Different media are commonly used as substrate in various hydroponic techniques. Nature of media used in hydroponic systems affects plant growth and development directly and indirectly. The objective of this study was to examine the effect of some growing media on growth and yield of cherry tomato ( Lycopersicon esculentum var. cerasiforme) and also nutrient concentration and uptake of this plant. The study was carried out in a greenhouse using a completely randomized block design with 9 treatments,4 replicates and two plants in each plot. Nine different growing media including cocopeat, perlite, rice hull and mixture of perlite-mica, perlite-zeolite, rice hull-mica, rice hull-zeolite (50:50 v/v) perlite-rice hull-zeolite and perlite-rice hull-mica (37.5+37.5+25 v/v) were tested. Water and nutrient requirements of plants were applied with a drip irrigation system without re-utilization of drained nutrient solution. The lowest yields were obtained from the rice hull and mixtures of rice hull with other materials. The highest yields, the largest shoot dry weight and the greatest number of cluster per pot, were obtained from cocopeat and perlite-mica media. Perlite-mica mixtures may be used successfully ,therefore, as an alternative for the imported cocopeat as a growing media. Cocopeat and mixtures of zeolite with perlite or rice hull gave a higher concentration of K and Mg in plant tissues and fruit of cherry tomato, whereas mixtures with mica resulted in higher Ca concentration in plant and fruit compared to the cocopeat and zeolite-containing media. Rice hull and mixtures of rice hull with mica and zeolite gave a higher concentration of Mn compared to other media. Higher uptake levels of K and Mg as compared to the other media, were observed in cocopeat and zeolite(50%)-containing media, whereas Ca uptake was higher in mica-contaning media. Higher uptake of Mn compared to the other media, were detected in the perlite-mica and rice hull-containing media.