Industrialization and urbanization processes have resulted in environmental pollution through a wide range of chemicals over the past few decades and threat humans and other organisms health. Heavy metals are the most important environmental pollutants that made soil and water polluted. The most common heavy metals in soil and wastewaters are zinc and copper. Interactions between metal ions and soil constituents can affect metal toxicity to plants and micro-organisms, and mobility to the ground waters. Sorption processes are the most significant chemical reactions of heavy metals in soil. Due to presence of various clay mineral and organic matters in soil, investigation of interaction between heavy metals and pure minerals can help to better understand the behavior of these metals in the soil. This study examined interaction between zinc and copper with sepiolite and palygorskite, as clay minerals that are frequently found in arid and semiarid regions soils. In order to determine sorption capacity of sepiolite and palygorskite for Zn and Cu based on isotherm models, different concentrations of these ions were equilibrated with the clays in 1%suspensions.for 24 h. Results showed that Langmuir and Freundlich models were the best models describing Cu sorption on sepiolite and palygorskite, respectively. Similar results were obtained for Zn sorption on the minerals. Considering the importance of thermodynamic data to determine the physicochemical behavior of copper and zinc in soil environment, sorption of copper and zinc on sepiolite and palygorskite at four different temperatures (15, 25, 35 and 50 ?C) were studied. Negative values of Gi free energy changes and positive values of enthalpy changes refer to spontaneous and endothermic nature of copper and zinc sorption on sepiolite and palygorskite, respectively. Positive values of entropy changes of Cu and Zn sorption on the clay minerals are indicative of system disorder increase due to structural changes. Considering the thermodynamic parameters showed that chemical sorption is probably the main mechanism of copper and zinc sorption on sepiolite, but sorption of these metal ions by palygorskite is more physical and probably the diffusion is the key mechanism in this process. In this study sorption kinetics of copper and zinc by sepiolite and palygorskite was also investigated and the role of temperature on the quantity and rate of sorption was determined. Several kinetic models were used to explain the rate constants of adsorption processes as affected by temperature. Elovich model was selected as the best model for describing Cu and Zn sorption kinetics on palygorskite. The Elovich, parabolic and power function models indicated best fit for Zn sorption on palygorskite in 15, 25 and 35 ?C, respectively. Power function and parabolic models were selected as the best models for describing sorption data of Zn and Cu on sepiolite.. Overall, equilibrium, kinetic and thermodynamic sorption parameters of Cu and Zn by palygorskite and sepiolite are greatly influenced by temperature. Key words : Palygorskite, Thermodynamic, Zinc, Sepiolite, Kinetic, Copper.