The high pollution of environment with heavy metals due to the application of various industrial wastes and sluges has forced researchers to develop several ways to remove and/or decrease the harmful impact of these metals. Absorption of these elements by natural materials is one of the best controlling methods. In this research, Iranian natural bentonite, zeolite and sepiolite minerals in the presence of calcite have been used as absorbent of nickel and cadmium. Sepiolite and bentonite samples were obtained from Yazd mines while the zeolite sample was taken from Siahzagh mine in Semnan. X-ray diffraction and, elemental analyses and cation exchangable capacity measurment of the minerals were carried out. After the removal of carbonate from samples, they were mixed with 0, 5, 10 and 20% (by weight) of analytical grade calcite. All the sorption experiments were conducted with batch methods in 0.01 M Ca(NO 3 ) 2 solution with 3 replications at labratory tempreture (23±2°C) and with sorbent concentrations of 1%,. A volume of 30 ml of Ni(II) and Cd(II) solutions with 0.3g of sorbents was placed in polyethylen tubes. The initial concentrstion of Ni(II) and Cd(II) for all the sorbents ranged from 5 to 250 mg L -1 and 5 to 180 mg L -1 , respectively. The suspensions were shaken for 24 h by a rotary shaker and then centrifiuged at 2000g for 10 minutes. The Ni(II) and Cd(II) concentrstions of the supernatant were determined by an atomic absorption spectrophotometer. The pH of the equilibrium solution was also randomly measured.The Freundlich, Langmuir and Koble-Corrigan adsorption models were well fitted the sorption data. Bentonite and sepiolite had maximum sorption of Ni(II) and Cd(II), respectively. Adsorption of both elements increased with an increase in calcite content of the sorbent system. This could be attributed to the increase in pH and also the produation of new species of metals and the precipitation of metals. Bentonite adsorbed the highest amount of Ni, whereas sepiolite could adsorb the highest amount of Cd. Kinetic sorption experiments of Ni(II) and Cd(II) were carried out under the same conditions as the sorption isotherms, but with the initial concentration of 250 and 180 mg L -1 , respectively, for a period of 15 minutes to 24 h. The results indicated the kinetic sorption of both elements were well fitted with eluvich, power function and parabolic diffiusion kinetic models. The time needed to reach equilibrium depends on the type of sorbent (mineral) and the amount of calcite added. The higher the amount of calcite, the higher the rate of sortion. For a given time period, the amount of Ni(II) sorbed by bentonite and that of Cd(II) sorbed on sepiolite were higher than the other systems. Desorption experiments were carried out on enriched sorbent samples using Ni(II) and Cd(II) solutions with the concentrations of 250 and 180 mg L -1 , respectively, in the background electerolyte solution of 0.01 M Ca(NO 3 ) 2 . Desorption Experiment continued until the concentration of Ni(II) or Cd(II) reached below the detection level of the atomic absorption spectrophotometer. The results indicated that the major content of sorbed Ni(II) and Cd(II) on bentonite was released and the adsorption on this mineral seemed to be reversible and non-especific. The presence of calcite could reduce the Ni(II) desorption from bentonite but did not influence the Cd(II) desorption. Ni(II) and Cd(II) desorption from zeolite was less that of bentonite and decreased with calcite addition. The amount of Ni(II) and Cd(II) desorbed from sepiolite was less than that from the other minerals showing that the sorption of these metals on sepiolite was specific and irreversible. In general, among the 3 minerals, sepiolite having 20% of calcite appears to be the best sorbent for the removal of Ni(II) and Cd(II) from aqueous solution. Key Words : Clay mineral, contamination, mixed sorbent, hystersis, adsorption isotherm, kinetics.