Advancements in science and technology has led to growth of population and development of pollution in different regions of the world specially in industrial and agricultural regions. Area of unused and contaminated soil is increasing. Finding simple and inexpensive methods is the goal of many scientists. One of the popular and frequently used methods is Phytoremediation. Phytoremediation is utilization of plants to remove and stabilize organic and mineral pollutants, which is a compatible with environment, inexpensive, and proper for large area utilization. One of the newest solutions suggested to increase the function of Phytoremediation is the using beneficial soil microorganisms’ symbiotic relationships with plants. Piriformospora indica has a strong stimulatory effect of plant growth and increasing resistance to environmental stresses such as salinity, drought, disease and soil pollution. This study examines the potential of Endophyte P.indica in the absorption of zinc and cadmium by maize and sunflower plants. Greenhouse experiments were performed in 4 kg-pots in sand and perlite in a randomized complete block design in a factorial arrangement in triplicate in greenhouse soilless cultivation in Isfahan Industrial University. Experimental factors included 2 levels of fungi P.indica (inoculated and non-inoculated), 4 levels of zinc (0, 50, 100 and 150 mg/kg) and 4 levels of cadmium (0, 0.5, 2 and 4 mg/kg). Analysis of the simple effects of fungi on aerial organ dry weight biomass and plant root revealed that in majority of case biomass of inoculated plants is significantly increased compared to fungus-free plants. In addition, results of fungal interactions and treatments displayed that in majority of cases in aerial organ and all root levels, plants inoculated with higher amounts of fungus accumulated higher concentrations of zinc and cadmium. The results of this study imply that the concentration of heavy metals zinc and cadmium levels in roots of sunflower was higher than aerial organ. Additionally, sunflower has accumulated much higher levels of elements compared to maize. These results are promising for the use of fungi P.indica for Soil Phytoremediation from heavy elements.