Salinity and drought are the most common environmental stresses which have endangered successful crops production. The vast cultivated areas in Iran are located in arid and semi-arid parts of Iran, so these plants are subject to adverse environmental conditions. Hence to increase plants tolerance to environmental stresses mostly due to water scarcity and exceeding soil salts mineral is important in terms of yield losses. Biological methods based on soil useful microorganisms’ potentials in creating symbiosis relationship to plants can increase crops yields per unit area by changing their genetic structure, improving their cultivation in saline, dry soils or biotic and abiotic stresses. The present research deals with effect of simultaneous inoculation of Piriformospora indica and symbiotic rhizobia strains with bean on different growth index under drought and saline stresses during two separate experiments. For this, a laboratory experiment as factorial in randomized completely design was conducted in soilless research center located in Isfahan university of technology. Experimental treatments included two fungi levels (inoculation and without inoculation), three rhizobia bacteria levels (Rb141,Rb 122 and without rhizobia), three salinity levels (0,35 and 70 m mol NaCl), three drought levels (FC, 50% FC and 25%FC), which evaluated in thrice replicates. The results showed that the highest shoots and roots weight under all exerted salinity levels is belonged to fungi P.indica and rhizobia Rb 122. Increased salinity level reduced control aboveground organs potassium potential (without fungi and bacteria) but in fungi or bacteria inoculated plants, there was not significant change in abovementioned element concentration. Shoot and root sodium concentration was increased in all studied treatments under increased salinity level so that it was more appreciable in control plants. Root phosphorous concentration inoculated with P.indica and also simultaneously inoculated plants by fungi and bacteria was increased. The highest roots P under all salinity levels was recorded in plants inoculated with Rb 122 fungi and rhizobia. As salinity level was increased, the more activity of Catalase and peroxidase was observed in rhizobia inoculated plants to Rb122 and 141 respectively. Increased activity of aforementioned enzymes under salinity stress in p.indica inoculated plants also was observed but in controls one, just catalase activity was increased. Unlike all experimental treatments which under salinity stress, shoot and root nitrogen were increased, the simultaneous inoculated plants with fungi and bacteria did not show significant change in concentration of this element. Results related to drought stress experiment indicate that increased drought stress reduces shoots dry weight of all studied plants. But among plants inoculated by fungi and bacteria, the plants inoculated to fungi P.indica showed less reduction of this index than simultaneous inoculated ones. Drought reduced potassium concentration of roots in all treatments significantly but those inoculated with fungi had higher potassium in their roots. Also implementation of drought stress reduced p concentration of root and shoot so that inoculated plants to P.indica had higher p in their roots. Increased drought level lessened nitrogen in shoot and root but comparison of plants inoculated to bacteria and fungi implied to higher nitrogen concentration in inoculated plants root with Rb122 than those of inoculated to Rb141. It is worthy to note that nitrogen rate of plants roots inoculated by simultaneous fungi and bacteria was much more than those inoculated individually and control ones. Keywords: Piriformospora indica, rhisobium, red bean, salinity stress, drought stress