Drought is the most important environmental factor that limits crop yield through the world. About 96.7 percent of Iran ’s land is classified as arid and semiarid climates. Wheat is one of the three most important cereals in the world and its quality properties are affected by drought. The objectives of this research were to find the effect of different irrigation regimes on quality, yield and yield components of two wheat cultivars (namely the bread and durum cultivars). The experiment was conducted at Lavark farm (Isfahan University of Technology's specialized research farm) using a randomized complete block with a split layout and replicated three times. Five irrigation regimes (I 1 : 70mm, I 2 : 90 mm, I 3 : 110mm, I 4 : 130mm I 5 : 150mm) were used as main plots and two wheat cultivars (Roshan and Shwa) were subplots. Hectoliter weight, starch percent, starch amylose content, fat percent, protein percent and the amount of minerals in whole grain were measured as quality parameters and plant height, number of spikes per square meter, leaf area index, spike length, kernel number per spike, weight of 1000 kernels, grain yield, straw yield and harvest index as yield and yield component parameters were measured. All yield components, except harvest index and spike length, were decreased as drought levels increased. Hectoliter weight, fat percent and starch content decreased, while protein content and mineral concentration increased when severe drought occurred. Reduction of kernel weight and dilution effect added the protein percent and grain's mineral concentrations in moisture deficit conditions. The highest variations in quality parameters were observed in I 4 treatment, because of the short and stressful grain filling period. These results show that starch accumulation was more sensitive to moisture deficit than protein accumulation. Nitrogen, copper and manganese varied more than the other minerals due to moisture stress but protein and mineral yields decreased under drought conditions. Grain yield was affected by irrigation regimes and reduced to 48.3 percent in Shwa cultivar and 25.7 percent in Roshan cultivar. This showed that Shwa cultivar was more sensitive to moisture deficit, but this cultivar (Shwa) had higher grain yield under sufficient water situation than Roshan and produced less straw yield than Roshan . Number of spike per square meter, kernel 1000 weight and kernel number per spike showed high correlation with grain yield, respectively. Finally, both moisture deficit and irrigation schedule, affected grain quality, yield and yield components of two cultivars. Grain quality properties were affected by moisture deficit and both protein and minerals yield decreased even thought their concentrations