The aim of thisstudy was to determine the effect offeeding different levels of transfusion on growth performance, blood parametersand some immune responses in Holstein calves. Forthis purpose, 39 Holstein calves were assigned to 3 treatment with 13replicates each.The calves entered to exprement were 3 days after birth and left from the projectone week after weaning (67 days). Treatmentswere: 1- control group (30% common soybean meal), 2- groups fed by 10% soybeanmeal processed with 20% common soybean meal, 3 groups fed by 15% soy processedmeal with 15% soybean meal Normal Feedconsumption was recorded on a daily basis. To measure blood cells and bloodmetabolites, blood samples were collected from the neck of the vein for 2 daysbefore slaughter, 1 day after weaning and 3 days after weaning. Serummetabolites including glucose, insulin, albumin, total protein, antioxidantcapacity, alkaline phosphatase and inflammatory markers (IL-1) and amyloid A(SAA) serum were determined. The results showed that Feed intake increasedgroup received 15% of treated soybean meal in the third week was significant (P= 0.04), fourth was significant (P = 0.01) and sixth was significant (P = 0.02)and also week nine was significant (P =0/04).Daily gain was also increased inthe group receiving 15% soy processed meal in the fourth week was significant(P = 0.01)and sixth was significant (P = 0.02) as well as week nine v (P =0.04). The consumption of 15% of treated soybean meal increased the shoulderheight at 30 days of age (P = 0.0007) and after weaning (P = 0.002), apicalheight at 30 days (P 0.0001) and after slaughter (P 0.001) and increasedthe chest circumference after weaning was significant (P = 0.01) Consumption of 30% common soybean meal increased the percentage oflymphocytes in 3 days after weaning was significant (P = 0.05). 10% consumptionof processed soybean meal increased the neutrophil ratio to lymphocyte within 3days after weaning was significant (P = 0.04).Consumption of 15% of treatedsoybean meal reduced white blood cell count in 1 day after weaning wassignificant (P = 0.05) and 3 days after weaning(P = 0.04). 10% consumption ofprocessed soybean meal increased glucose in 1 day after weaning was significant(P = 0.05). However, 15% of treated soybean meal increased glucose levelswithin 3 days after weaning (P = 0.006). 15% consumptionof processed soybean meal reduced insulin in 2 days before weaning (P = 0.001)and 3 days after weaning (P = 0.004).Consumption of 30% common soybean mealincreased total antioxidant capacity in 3 days after weaning (P = 0.005).Consumption of 15% of treated soybean meal reduced SAA in 2 days before weaning(P = 0.02) and 3 days afterweaning (P = 0.03). Also, the highest concentrationof SAA related to the control group was before and after weaning. The consumption of 15% of treated soybean meal was due to decreasein IL-1 concentration in the 2 days before weaning (P = 0.03) and 3 days afterweaning (P = 0.04) was sigificant. Also, the highest concentration of IL-1related to the control group before and after weaning. The results of thisexperiment showed that consuming 15% of soybean meal in the initial calf feedwould improve the performance, health and safety of calves. Keywords : Processed Soybean Meal , MilkCalves , Function, Immunity