In recent years, a large amount of pollutants such as Cadmium and Lead, due to increase in human activity and usage of fuels, have been released into the environment and contaminated food and water. Now millions of people in all around the world have been exposed to being poisoned with heavy metals. Heavy metals are elements that have no biological role in body and can cause various toxicity. Available conventional methods (precipitation, flocculation, ion exchange, and membrane filtration) for removal of these metals from water at low concentrations are claimed to be too expensive and inefficient. It has been reported that on average 50% of ingested toxins is absorbed into the human body and causes adverse effects on skin, internal organs and nervous system. Up to now, no specific treatment for poisonous heavy metal has been clinically confirmed and chelation therapies, the most direct treatments to alleviate heavy metals toxicity by promoting metals excretion, are deficient in safety and efficacy. Therefore, novel strategies against heavy metals toxicity need to be developed. Some evidence suggests that the gut microflora can reduce the absorption of toxins in body; so in this study, the ability of 19 strains of local lactic acid bacteria in reducing Cd 2+ and Pb 2+ in vitro had evaluated. So the amount of microorganisms were suspended in ultrapure water and diluted to a final bacterial concentration of 1 g/L and a final metal concentrations of 50 and 10 mg/L for Pb 2+ and Cd 2+ , respectively. Then the suspensions were incubated for 1 hour in 37°C . After that suspensions were centrifuged at 8000 ×g for 20 min, and the amount of metal that remains in supernatant was analyzed by atomic absorption spectrometry. The results showed that all lactobacillus strains could adsorb Cd 2+ and Pb 2+ , but the amount of adsorbing was different in each strains. Also the effect of heat treatment, metal concentration, pH and contact time was analyzed in Lactobacillus plantarum su. Plantarum (PTCC No. 1896), had the highest uptake of Cd 2+ and Pb 2+ . The results showed that pH has the great impact on the uptaking of metal ions that showed ion exchange mechanisms could be involved in adsorbing. Also with increasing in metal ion concentration, the absorption increased until maximum capacity (q max ) of bacteria. After that, increased in metal ion concentration, had no effect in biosorption. So experimental results from metal removal were fitted to theoritical model which enables calculation of specific descriptive parameters. In this work, metal removal ability of LP. PTCC 1896 was evaluated by using a Langmuir isotherm and the amount of q max was Cd 34.5 ± 2.9 mg/L and 122.7 ± 37.3 mg/L for Pb 2+ and Cd 2+ , respectively. Base on the results, removal was fast, metabolism-independent surface process and more incubation (more than 1 hour) had no effect. Also heat treatment had different effects on biosorption. Biosorption of Cd 2+ after heat treatment was increased whereas the amount of Pb 2+ that adsorbed was decreased. Base on the results of this study and results of the other researchers, it is suggested that lactic acid bacteria can be used in food formulation, especially food contaminated with heavy metals. Keywords : heavy metal, Lactic acid bacteria, biosorption, detoxification, bioremediation