Insect Growth Regulators with effective control on larval stage of insects could replace conventional insecticides. Considering the importance and the amount of damage of the Galleria mellonella to honeybee combs and confronting with problems in controlling this pest with conventional insecticides and adverse effects of usage of these compounds for honeybees and human beings, the possibility of using IGRs for controlling this pest was evaluated. In this study Diflubenzuron as a chitin synthesis inhibitor with a dosage of 25 mg A.I/L, and Pyriproxyfen as a juvenile hormone analogue with a dosage of 0.4 mgA.I/L were incorporated the wax diets of young and last instar larvae of greater wax moth and reared at different temperatures (20, 25, 30, 35°C). Young larval instars that were reared at 20?C were not able to complete their life cycle during the experimental period. Results showed that these compounds in comparison with control increased larval mortality. Diflubenzuron and Pyriproxyfen caused 33.9% and 24.1% mortality respectively. The last larval instar showed higher mortality with mean of 57.8% in Diflubenzuron and 31.5% in Pyriproxyfen. In evaluation of pupation and emergence of adults, no significant differences were observed between Diflubenzuron and control. Pyriproxyfen induced reduction in pupation about 48.4% and adult emergence about 44.8%. and caused some abnormalities of pupae. Last larval instar was more sensitive to JHA in this respect. Maximum pupation disruption occurred at 25?C and 30?C in comparison to 35?C which reduced abnormal pupae up to 19.7%. Adults abnormality in treated Pyriproxyfen (44.9%) was higher than Diflubenzuron (31.3%). JHA was effective on last larval instar and increased abnormality of adult up to 61.6%. This compound at 35?C increased Adults abnormality up to 69.7%. Pupal period of young larval instar treated with Pyriproxyfen, increased to 11.1 day. But this compound when used on last larval instar caused reduction of pupal period to 8.6 day. The pupal period reduced with the increase of temperature. Pupal period at 25?C with 13.5 day reduced to 7.5 day at 35?C. Pyriproxyfen caused increase of life span. Life span in control was 47.1 days, which increased to 88.8 days on Pyriproxyfen treated larvae. Male adult emergence increased in Pyriproxyfen (58.4%). Reproductive potential (egg viability, hatchability) of adults reduced in F1 generation and was 70-90 percent. Female adult Weight in Diflubenzuron and control was 0.12 mg but increased to 0.19 mg under Pyriproxyfen treatment. Evaluation of percent pupation, adult emergence and abnormal adults at last larval instar which treated at 20?C showed that the effect of this temperature is similar to 25 and 30?C. At this temperature pupal period increased to 27.7 days. Relative growth rate of larvae exposed to tr