Heavy metals are considered as the toxic and persistent pollutants in the environment especially in aquatic environments that can adversely impact on the ecosystems. These elements are found in the water as soluble and insoluble ions, organic/inorganic complexes or accompanied by colloidal and suspended materials. Nowadays, there are various techniques for removing heavy metals from water but most of them have the high costs of investment, operation and maintenance and/or low efficiency. Adsorption process is one of the economic and efficient methods to remove pollutants from aquatic environments. In recent years, biosorption using adsorbents prepared from non-living organisms such as bacteria, fungi, algae and organic materials such as rice husks, fruit skins leaves, bark, etc. have been taken more attention. The purpose of this study is the removal of cadmium and lead using green algae biomass of Scenedesmus quadricauda . In order to prepare the sorbent, the biomass of the algae after cultivation and harvesting in vitro, was dried and inactivated by Freeze Dryer. Adsorption experiments were designed in the both batch and column, and the parameters affecting adsorption including equilibrium time, initial pH of metal solution, initial concentration of metals and amount of adsorbent were investigated. Some physical, chemical and morphological characteristics of sorbent were determined by elemental analysis, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy methods. The results showed high adsorption rate of cadmium and lead (equilibrium time a bout 15-20 minute). Study of adsorption kinetics also represented a better fit to the pseudo-second-order kinetics for the sorption of cadmium and lead ions by the adsorbent. Adsorption of cadmium and lead was increased with increasing the pH in the range of 2-5 , so that the optimum pH for both metals adsorption was five. Lead and cadmium adsorption were fitted better by Redlich-Peterson and Langmuir isotherms models than the Freundlich model. Maximum adsorption of cadmium and lead was predicted 135 and 333 mg/g by Langmuir equation, respectively. With increasing the amount of adsorbent from 0.05 to 0.7 g/L, the adsorption percentage of cadmium and lead at a concentration of 50 mg/L was increased about 3.5 and 3 folds, respectively. Column experiments showed that the sorption performance is up to 40% for lead ions (amount of adsorption 219.3 mg/g) and 16% percent for cadmium ions (amount of adsorption 76 mg/g), and has high ability desorption (90%) by nitric acid 0.5M for both metals. Hence it is possible to apply this sorbent in successive adsorption cycles. Results of heavy metal adsorption from an industrial city wastewater sample indicated that cadmium and lead adsorption percentage were 65 and 69%, respectively. Keywords: Heavy metals, Microalgae, Scenedesmus quadricauda , Adsorption, Aqueous solutions