Nowadays communities experience various changes and they encounter more changes in future. One of the changes which affected communities during past years and will have effects on them in future, is extreme changes of natural resources and environment in the earth which caused by human destructive activities. Human causes disturbances in environment and disturbs balance between ecosystems parts more than others. Disturbing effect of human on other creatures has not high precedence on the earth and this phenomenon is relatively new which is caused by human population increase in recent years, increase of human diverse needs and dominance of human in nature. Considering current level of human knowledge and technology, accessing to a huge information bank about natural resources changes is possible by remote sensing technique, without spending much money. Using Remote sensing technique and Geographic Information System in natural resources evaluation and management is cheaper than traditional methods and they are economical because of their speed. Sejzi which is located in the east of Isfahan city is one the most important centre of desertification in Isfahan province. High amount of sandy places exploitation, chalk mines utilization, traveling of trucks having chalke and presence of furnaces are factors which prevent desertification. Sejzi resources exploitation, Such as chalk mines cause disturbance of soil surfaces and produce particles with low stability which are gone through the wind and pollute east of Isfahan . Earth formation changes and unsuitable landscape are the impacts of human huge taking. The main goal of this study is evaluation of operation and capability of LISS IV, IRS P6, IRS P5 satellite data in destructed lands and Sejzi large holes detection, which are caused by human huge taking and shows decline of earth biological and ecological situatio and presence of desertification in this area. For using images in evaluation of land disturbance and desertification in study area, high quality and ground precision is considered in selection and ordering data. Because of special situation of study area and presence of huge artificial and anthropogenic topography in relatively flat plain without huge natural elevation, image with high spatial resolution, X, Y and also Z must be used. So image of modern and most advanced LISS IV, IRSCartosat-1 (P5), ResourceSat-1(P6) are selected and their ability in preparation of these area map is also considered. At first, A band of P6 satellite image georefrenced to digital map at a 1:25000 scale. Nearest neighbor method and first-order polynomial model were applied.