Hydroxyapatite (HA) has been extensively studied and clinically applied for both its bioactive and properties in medicine and for its biological and chemical similarity to the organic phase of bone and teeth. HA is too brittle to be used as bulk material under loaded conditions. For a successful application of HA ceramics in load bearing areas of human body, it is necessary to improve its mechanical properties. One way to overcome this restriction of HA is to use HA as a matrix in a composite and other bioactive reinforcement ceramic or metal. In recent years, most of researches about HA have focused to develop HA based bioceramic composite. Recently, it has been reported that Titania and HA represent a good combination for functionally graded materials providing a gradient of bioactivity and good mechanical properties. Moreover Titania is able to enhance osteoblast adhesion and induce cell growth. The methods of manufacturing nanostructured composites are different and can they include spark plasma sintering, hot pressing and Two Step Sintering. Two step sintering (TSS) has been applied, in the present work, to suppress the accelerated grain growth of Hydroxyapatite (HA) and Titania (TiO 2 ) nanoparticles in the HA-TiO 2 composites in the last sintering stage. Two step sintering method is a clear example of a multivariable process that demands important resource and time consuming efforts in order to optimize firing schedules. Most of researchers, apply this process based on try and error method. When the number of factors and parameters settings is high, the experimental plan yields an undue number of experiments. Nevertheless, experimental planning may be optimized based on partial factorial experimental plans. Among the existing methods, the Taguchi approach is particularly attractive for simplicity and clarity of use it. This work presents an integrated approach to assess optima two step sintering schedules of HA-15wt.%TiO 2 that combines predictions of the sintering kinetics based on conventional sintering data with Taguchi fractional experimental plans. It was shown by application of Two Step Sintering method, the final grain size of HA-15wt.%TiO 2 maintain lower than 100nm while by application of conventional sintering it reaches higher than 100nm. X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infra Red (FTIR) and Archimedes method were used to characterize powders and bulks prepared by TSS method. To find how important, the temperatures at sintering steps might be, several TSS regime were conducted. The results showed that the temperatures were critical at both sintering stages. The optimum regime consisted of heating the green bodies up to 1150?C in the first step of sintering and then holding at 1050?C for about 25h in t