In recent years, mesoporous hydroxyapatite has been widely considered for its high biocompatibility properties, its direct bonding with bone, and the potential for use in delivery systems for controlled drugs. According to different methods of hydroxyapatite synthesis, in this research, the synthesis of mesoporous particles of hydroxyapatite was done by hydrothermal and precipitation methods. In the first method, the synthesis of the hydroxyapatite particles in the presence of Poly sodium styrene sulfanate () in water was investigated. The results of X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray diffraction spectroscopy (EDX) showed the presence of impurity particles in the produced hydroxyapatite powder. Therefore, the synthesis of nanostructured, high-grade mesoporous hydroxyapatite particles was investigated during low temperature precipitation method. This structure was successfully prepared with the calcium carbonate mineral form produced in the presence of ethylene glycol. Characterization of particles was performed by X-ray diffraction (XRD), scanning electron microscopy (SEM), field scanning electron microscopy (FESEM), X-ray energy spectrometry (EDX) and infrared Fourier transform (FTIR) spectroscopy. Porosity Test (BET) and Particle Size and Particle Size Distribution (DLS, Zeta potential) were evaluated on the produced particles. The results of the study showed that the produced ovoid hydroxyapatite particles with a particle size distribution of 693.48 nm with nano-layered sheets and an average pore size of 20 nm are in the mesoporous particle group. Subsequently, the possibility of using nanoparticle particles of hydroxyapatite mesoporous in delivery systems using ibuprofen as a model drug was also studied. X-ray diffraction (XRD), scanning electron microscopy (SEM), infrared Fourier transform (FTIR) spectrometry, thermal weighing analysis (TGA), and UV scrophotometry tests were performed to prove drug loading. In this way, the results of tests, high loading capacity and controlled release of nanostructured particles of mesoporous hydroxyapatite showed. In the antibacterial test, Escherichia coli bacterium was produced against the nanoparticles of mesoporous hydroxyapatite and the particles containing the drug were resistant. If the bactericidal effect of the hydroxyapatite particles and the particles containing the drug were observed on Staphylococcus aureus bacteria. According to the results, the produced particles have a wide application in bone injury.
