Bone as a hard tissue in the body has the task of protecting and protecting various organs, while facilitating movement. The repair of large bony lesions with normal bone function is not necessary and requires the intervention of a surgeon. The new solution to the treatment of defects and bone diseases is the use of artificial scaffolds. The purpose of this study was to construct biocompatible bone scaffolds of polymer-glass with a protein-coated bioactive coating. Sub-micron particles of bioactive glass were synthesized with dimensions of 720 ± 80 nm (n = 30). Polyacroplacten / gelatin fibers were electrically charged by using 2.5% wt. Of these particles in the structure. The fibers were completely uniform and the diameter of these fibers was calculated to be 60 ± 250 nm (n = 70). The results of this study showed that the nano / micro-fibers produced are highly bioactive so that after only 5 days of immersion in the simulation of the surface of the body, they are completely covered with hydroxyapatite. The study of the wetting angle showed that these fibers are completely hydrophilic. Cell testing confirmed the fiber support of adhesion and cell proliferation. After 14 days of cultivation of dental pulp stem cells, the Alizarin reed test was performed and it was shown that the fibers were differentiated into dental pulp cells into bone cells. Such behavior was carried out in the absence of osteogenic factors and only due to the presence of bioactive glasses, which is very important in this regard. In the second part of the present study, bioactive glass nanoparticles with a diameter of 70 ± 15 nm (n = 40) were synthesized. The polyacroplacten / gelatin fibers contained 1.25, 2.5 and 5 wt.% Of nanoparticles of biodegradable glass electrodes. The results of the tensile strength test showed that the particles containing 5 wt% of tensile strength of 12.7 ± 0.7 MPa, 91 ± 11% increase, and 79 ± 9 MPa elastic modulus have better mechanical properties than other fibers. Therefore, these fibers were selected as optimal. The images of the electron microscope passing through the optimum fiber confirmed the presence of particles in the fiber. Also, the bioactive effect of these fibers was confirmed by immersion in a body simulation solution and the formation of hydroxyapatite after 10 days. Protein fibronectin and serum albumin were bonded to the surface of non-hydroxyapatite fibers and superficial hydroxyapatite. The presence of proteins on the fiber surface was confirmed by the infrared spectroscopy test and the study of the amplification of amylated ligaments. Quantitative studies with ultra-violet-visible test showed that the amount of protein absorbed on the surface of hydroxyapatite was higher than that of non-hydroxyapatite (498 ± 23 ?g / ml versus 363 ± 54 ?g / ?g). In order to evaluate the ability of fibers to be used as drug carriers, nanoparticle fibers containing 3% by weight of amoxicillin were electronized and their release rate was investigated. It was shown that the fibers released the drug during two stages of its explosive release and slow release, so that for non-crosslinking fibers, 70% of the drug was released only in the first hour and its release until the end of the 24 hours Gradually completed. The release rate for crosslinked fibers was lower. The study of the bactericidal properties of the fibers against Staphylococcus aureus and Escherichia coli bacteria and the measurement of the diameter of the non-growth hole showed that the fiber containing the drug was either crosslinked or crosslinked, against Staphylococcus aureus Aureus has an antibacterial property, but it does not have bactericidal properties against E. coli.