Titanium dioxide (TiO 2 ) is one of the most commonly titanium compounds in the industry, which has the most application against other titanium compounds. This compound, mostly, is used as a pigment because of its properties. Characteristics such as chemical resistance, antibacterial, low-toxicity and self-cleaning have led to use in various applications such as electronics, cosmetics, water purification, and environmental degradation. Important titanium sources are titanium minerals that are naturally occurring in the form of oxides ore. Two important titanium minerals are, ilmenite and rutile, which is rutile include titanium and oxigen, and ilmenite include iron, oxygen, and titanium elements. In this research, ilmenite of Kohnooj mine in south of Kerman, Iran, has been used as a titanium source and purpose is optimization of the synthesis TiO 2 mesoporous nanoparticles process with the least amounts of iron content. The effect of main parameters, temperature, solids to acid ratio and acid concentration on the dissolution of ilmenite concentrate and iron removal in its structure were investigated and it was concluded that the acid concentration was more effective in dissolution of iron and titanium. To design of experiment, CCD method was used by Design-Expert software and ANOVA and RSM methods ware used to analyze the results. The solubility of titanium and the solubility of iron were considered as the responses and the effect of the parameters on these responses was investigated. By using the 2D, 3D, and Cantor-plots, the interaction effects of the parameters on the responses was studied and it was concluded that the selected parameters have matual intraction. Also, by using HDTMA surfactant as surface direct agent, TiO 2 nanoparticles with a mesoporous structure in the anatase phase were synthesized from ilmenite concentrate, in order to enhance the photocatalytic characteristics by creating a mesoporous structure. In order to synthesis of mesoporous nanoparticles of TiO 2 , after removing iron from the ilmenite structure and increasing the weight percent of the TiO 2 in the ilmenite concentrate, remaind titanium in solid was solved as Ti-sol by H 2 O 2 solution, and then the gel was combined with HDTMA solution and after being in a hydrothermal condition and calcination, mesoporous nanoparticles of TiO 2 was synthesized in anatase phase. The mesoporous nanoparticles of synthesized TiO 2 were analyzed using different methods including TEM, BET, and XRD analysis. The results showed that the HDTMA has significant role in creation of porosity in structure of the TiO 2 with cylindrical shape and could improve the surface area more than 4.7 times. Also the difference in absorbency of the Tetracyclone antibacteria on the TiO 2 mesoporous nanoparticles and non porous structure was studied. According to results, the mesoporousity had important role in adsorption of Tetracycline.