Iron and Steel industries are one of the major infrastructures of each country, where due to its importance and depletion of high-quality iron reserves, steel industry is driven toward utilization of the low-grade deposits. The middle products of the Ehya Sepahan Iron ore company is considered to be one of the such low-grade deposits. The ore of the Sangan-Khaf (Razavi Khorasan) placer mine produces middle products, with 10 to 30 mm size after two steps of dry pre-processing and processing, which accumulated up to the volume of over three million tons with average Fe grade of 50%. Therefore, the goal of this study is set to investigate the feasibility of processing of such materials for marketable products. For the purpose of this study, some index sample was prepared and sample identification analysis such as, total Fe, iron oxides and major oxides determination and mineralogical studies (thin and polished sections) were performed. Separation methods such as: low intensity dry magnetic separation (DLIMS), Davis Tube, low intensity wet magnetic separation (WLIMS), and flotation were planned and conducted. Design Expert software was utilized to study the effect of operating parameters on the DLIMS and flotation outputs. Considering the developed response surface for DLIMS and flotation separation results, the parameter optimization was conducted and domain is extended by supplementary experiments, if necessary. The effect of magnetic field intensity, drum speed, angle of separating gate, and feed particle size on the DLIMS concentrate grade, recovery and separation efficiency were determined. Highest Fe grade of 59.84 % was obtained at magnetic field intensity, drum speed and angle of separating gate of 1200 G, 75 rpm and 83 degrees for -2 mm particles, which was upgraded to 60.08 % once particles were ground to -1 mm. The effect of collector and depressant type and dosage, and pulp pH on separation quality by flotation, were investigated. The maximum concentrate grade (optimized) of 63.63 was achieved for 1000 g/t, 1250 g/t of collector and depressant, respectively, at pulp pH of 8 for -53 ?m feed particles. The Davis Tube separator had its highest yield of concentrate grade, 62.73 %, at the field intensity and oscillation of 40% and 120 rpm, respectively, for -180 ?m particles, which increases to 65.02 % for finer particles (75 ?m). For WLIMS, the effect of magnet position and drum speed on the product grade, recovery and separation efficiency of the system were studied. Maximum concentrate grade of 64.98 % was achieved to be 64.98 % for -125 ?m particles separated at 80 rpm and magnet position of namely 1/2-1/2.